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Invitrogen
UBE2T Polyclonal Antibody
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Product Details
PA5-101948
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UBE2T(Accession Q9NPD8), corresponding to amino acid residues T72-D122.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total UBE2T.
Target Information
UBE2T is involved in the covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3). UBE2T catalyzes the covalent attachment of ubiquitin to protein substrates. Functionally, UBE2T accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, catalyzes monoubiquitination, is involved in mitomycin-C (MMC)-induced DNA repair, and catalyzES monoubiquitination of FANCD2, a key step in the DNA damage pathway. Defects in the UBE2T gene have been associated with Fanconi anemia of complementation group T.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell proliferation-inducing gene 50 protein; E2 ubiquitin-conjugating enzyme T; HSPC150 protein similar to ubiquitin-conjugating enzyme; Ubiquitin carrier protein T; ubiquitin conjugating enzyme E2T; Ubiquitin-conjugating enzyme E2 T; ubiquitin-conjugating enzyme E2T (putative); Ubiquitin-protein ligase T; UCE2; unnamed protein product
Gene Aliases: 2700084L22Rik; C80607; FANCT; HSPC150; PIG50; UBE2T
UniProt ID: (Human) Q9NPD8, (Mouse) Q9CQ37
Entrez Gene ID: (Human) 29089, (Mouse) 67196
nucleotide binding
chromatin binding
ubiquitin-protein transferase activity
protein binding
ATP binding
transferase activity
ubiquitin-like protein transferase activity
ubiquitin protein ligase binding
ubiquitin conjugating enzyme activity
ligase activity
ubiquitin protein ligase activity
ubiquitin-protein ligase
protein polyubiquitination
DNA repair
protein monoubiquitination
cellular response to DNA damage stimulus
protein ubiquitination
protein modification by small protein conjugation
protein K29-linked ubiquitination
protein K27-linked ubiquitination
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K6-linked ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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