The TMEM189-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this co-transcribed mRNA and the function of its protein product has not yet been determined.
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Protein Aliases: CROC-1; CROC-1UBE2V; CROC1B; DJ1185N5.1.3; DNA-binding protein; KUA-UEV; TRAF6-regulated IKK activator 1 beta Uev1A; ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1; UEV-1CIR1
Gene Aliases: 0610011J09Rik; AI256840; CIR1; CROC-1; CROC1; D7Bwg1382e; P/OKcl.19; UBE2V; UBE2V1; UEV-1; UEV1; UEV1A
Molecular Function: ubiquitin-protein ligase