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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 31-49 of human UBE2V1a.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: antigen standard for UBE2V1 (transient overexpression lysate), Jurkat, HeLa or RAW cell lysates.
The E2 enzyme, Ubc13, and the E2 enzyme variants, Uevs, form stable, high affinity complexes for the assembly of Lys63-linked ubiquitin chains. This complex has been shown to activate NF-kB signaling pathway by linking TRAF6 to IKKs. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results suggest a new regulatory function for ubiquitin, in which IKK is activated through the assembly of Lys63-linked polyubiquitin chains. The UEV proteins are also involved in the control of differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CROC-1UBE2V; CROC1; DNA-binding protein; TRAF6-regulated IKK activator 1 beta; TRAF6-regulated IKK activator 1 beta Uev1A; ubiquitin conjugating enzyme E2 variant 1; ubiquitin-conjugating enzyme E2 variant 1; UEV-1CIR1; UEV1A; UEV1DNA-binding protein
CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A