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Product Details
10344-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UBE3A Fusion Protein Ag0346 (9-215 aa encoded by BC002582)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: GEPQSDDIE ASRMKRAAAK HLIERYYHQL TEGCGNEACT NEFCASCPTF LRMDNNAAAI KALELYKINA KLCDPHPSKK GASSAYLENS KGAPNNSCSE IKMNKKGARI DFKDVTYLTE EKVYEILELC REREDYSPLI RVIGRVFSSA EALVQSFRKV KQHTKEELKS LQAKDEDKDE DEKEKAACSA AAMEEDSEAS SSRIGDSS (9-215 aa encoded by BC002582)
Target Information
UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. UBE3A also plays an important role in the regulation of the circadian clock. Defects in UBE3A are a cause of Angelman syndrome (AS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CTCL tumor antigen se37-2; E6-AP ubiquitin protein ligase; E6AP ubiquitin-protein ligase; FLJ26981; HECT-type ubiquitin transferase E3A; human papilloma virus E6-associated protein; Human papillomavirus E6-associated protein; Oncogenic protein-associated protein E6-AP; Renal carcinoma antigen NY-REN-54; ubiquitin conjugating enzyme E3A; Ubiquitin-protein ligase E3A
Gene Aliases: 4732496B02; 5830462N02Rik; A130086L21Rik; ANCR; AS; E6-AP; E6AP; EPVE6AP; HPVE6A; mKIAA4216; UBE3A
UniProt ID: (Human) Q05086, (Mouse) O08759
Entrez Gene ID: (Human) 7337, (Rat) 361585, (Mouse) 22215
Molecular Function:
ubiquitin-protein ligase
ovarian follicle development
proteolysis
ubiquitin-dependent protein catabolic process
brain development
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
androgen receptor signaling pathway
positive regulation of protein ubiquitination
sperm entry
regulation of circadian rhythm
positive regulation of transcription from RNA polymerase II promoter
protein autoubiquitination
prostate gland growth
protein K48-linked ubiquitination
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
biological_process
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of nucleic acid-templated transcription
rhythmic process
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
ligase activity
metal ion binding
ubiquitin protein ligase activity
molecular_function
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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