Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MFSFEGDFK TRPKVSLGGA SRKYSIQRSA FDRCATLSQS GGAFPIANGP NLTLLVRQLL FFYKQNEDSK RLIWLYQNLI KHSSLFVKQL DGSERLTCLF QIKRLMSLCC RLLQNCNDDS LNVALPMRML EVFSSENTYL PVLQDASYVV SVIEQILHYM IHNGYYRSLY LLINSKLPSS IEYSDLSRVP IAKILLENVL KPLHFTYNSC PEGARQQVFT AFTEEFLAAP FTDQIFHFII PALADAQTVF PYEPFLNALL LIESRCSRKS GGAPWLFYFV LTVGENYLGA LSEEGLLVYL RVLQTFLSQL PVSPASASCH DSASDSEEES EEADKPSSPE DGRLSVSYIT E (1-350 aa encoded by BC026241)
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HECT-type ubiquitin transferase E3C; HectH2; Homologous to E6AP carboxyl terminus homologous protein 2; RAUL; RTA-associated ubiquitin ligase; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); Ubiquitin-protein ligase E3C
Gene Aliases: AI853514; HECTH2; KIAA0010; KIAA10; mKIAA0010; RGD1559986; UBE3C
UniProt ID: (Human) Q15386, (Mouse) Q80U95
Entrez Gene ID: (Human) 9690, (Rat) 362294, (Mouse) 100763
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support