The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.
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Protein Aliases: homologous to yeast UFD2; Homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; RING-type E3 ubiquitin transferase E4 B; Ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitin-fusion degradation protein 2; ubiquitination factor E4B (homologous to yeast UFD2); ubiquitination factor E4B (UFD2 homolog, yeast); ubiquitination factor E4B, UFD2 homolog; UFD2A-III/UBE4B-III splice isoform
Gene Aliases: 4930551I19Rik; 4933406G05Rik; AU014668; D4Bwg0973e; E4; HDNB1; KIAA0684; mKIAA0684; UBE4B; UBOX3; UFD2; UFD2A; Ufd2p