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This antibody detects endogenous protein at a molecular weight of 90 kDa.
Purity is >95% by SDS-PAGE.
UBF-1 encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 90-kDa nucleolus organizer region autoantigen; Autoantigen NOR-90; NOR90; Nucleolar transcription factor 1; transcription factor UBF; UBF-1; Upstream-binding factor 1
Gene Aliases: A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1; UBF1; UBF2; UBTF
Molecular Function: DNA-binding transcription factor