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Invitrogen
UBR2 Polyclonal Antibody
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Product Details
PA5-37161
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human UBR2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 200 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase UBR2; KIAA0349; N-recognin-2; RING-type E3 ubiquitin transferase UBR2; ubiquitin ligase E3 alpha-II; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II; unnamed protein product
Gene Aliases: 9930021A08Rik; AI462103; AW540746; bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3; E130209G04Rik; KIAA0349; mKIAA0349; UBR2
UniProt ID: (Human) Q8IWV8, (Mouse) Q6WKZ8
Entrez Gene ID: (Human) 23304, (Mouse) 224826, (Rat) 363188
protein binding
zinc ion binding
transferase activity
metal ion binding
ubiquitin protein ligase activity
leucine binding
histone H2A ubiquitin ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein transferase activity
ubiquitin-protein ligase
ubiquitin-dependent protein catabolic process
reciprocal meiotic recombination
male meiosis
male meiosis I
spermatogenesis
negative regulation of transposition, RNA-mediated
protein ubiquitination
protein catabolic process
heterochromatin assembly
negative regulation of TOR signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
protein K63-linked ubiquitination
cellular response to leucine
ubiquitin-dependent protein catabolic process via the N-end rule pathway
chromatin silencing
histone H2A ubiquitination
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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