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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (PFA fixed) (IHC (PFA)) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human UBR4(Accession Q5T4S7), corresponding to amino acid residues I4019-E4040. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 150mM NaCl, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; N-recognin-4; p600; RBAF600; retinoblastoma-associated factor 600; retinoblastoma-associated factor 600-like protein; Retinoblastoma-associated factor of 600 kDa; RING-type E3 ubiquitin transferase UBR4; Zinc finger UBR1-type protein 1; zinc finger, UBR1 type 1; ZUBR1
Gene Aliases: 1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; KIAA0462; KIAA1307; mKIAA0462; N28143; p600; RBAF600; UBR4; ZUBR1
UniProt ID: (Human) Q5T4S7, (Mouse) A2AN08, (Rat) Q2TL32
Entrez Gene ID: (Human) 23352, (Mouse) 69116, (Rat) 313658
Molecular Function:
ubiquitin-protein ligase
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