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Product Details
PA5-116101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UBR4(Accession Q5T4S7), corresponding to amino acid residues I4019-E4040.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2900735
Target Information
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; N-recognin-4; p600; RBAF600; retinoblastoma-associated factor 600; retinoblastoma-associated factor 600-like protein; Retinoblastoma-associated factor of 600 kDa; RING-type E3 ubiquitin transferase UBR4; Zinc finger UBR1-type protein 1; zinc finger, UBR1 type 1; ZUBR1
Gene Aliases: 1810009A16Rik; A930005E13Rik; D930005K06Rik; Gm1032; Gm1666; KIAA0462; KIAA1307; mKIAA0462; N28143; p600; RBAF600; UBR4; ZUBR1
UniProt ID: (Human) Q5T4S7, (Mouse) Q8C8X7, (Rat) Q2TL32
Entrez Gene ID: (Human) 23352, (Mouse) 69116, (Rat) 313658
Molecular Function:
ubiquitin-protein ligase
ubiquitin-protein transferase activity
protein binding
calmodulin binding
zinc ion binding
ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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