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Proteintech
UCHL5 Polyclonal Antibody
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Product Details
11527-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UCHL5 Fusion Protein Ag2095 (1-326 aa encoded by BC025369)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTGNAGEWC LMESDPGVFT ELIKGFGCRG AQVEEIWSLE PENFEKLKPV HGLIFLFKWQ PGEEPAGSVV QDSRLDTIFF AKQVINNACA TQAIVSVLLN CTHQDVHLGE TLSEFKEFSQ SFDAAMKGLA LSNSDVIRQV HNSFARQQMF EFDTKTSAKE EDAFHFVSYV PVNGRLYELD GLREGPIDLG ACNQDDWISA VRPVIEKRIQ KYSEGEIRFN LMAIVSDRKM IYEQKIAELQ RQLAEEPMDT DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL KTLAEHQQLI PLVEKFEKHF EKTLLGK (1-326 aa encoded by BC025369)
Target Information
UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFβ-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: deubiquitinating enzyme; isopeptidase; INO80 complex subunit R; protein x 0012; ubiquitin C-terminal hydrolase 37; Ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; Ubiquitin thioesterase L5; UCH-L5; unnamed protein product
Gene Aliases: 5830413B11Rik; AD-019; CGI-70; INO80R; UCH-L5; UCH37; UCHL5
UniProt ID: (Human) Q9Y5K5, (Mouse) Q9WUP7
Entrez Gene ID: (Human) 51377, (Rat) 360853, (Mouse) 56207
telomere maintenance
regulation of DNA replication
DNA repair
regulation of DNA repair
DNA recombination
chromatin remodeling
proteolysis
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
protein deubiquitination
lateral ventricle development
midbrain development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of chromosome organization
positive regulation of DNA repair
positive regulation of smoothened signaling pathway
positive regulation of transcription, DNA-templated
regulation of embryonic development
forebrain morphogenesis
regulation of cell cycle
regulation of DNA strand elongation
regulation of proteasomal protein catabolic process
positive regulation of telomere maintenance in response to DNA damage
biological_process
negative regulation of endopeptidase activity
transcription, DNA-templated
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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