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Huabio
UCP1 Polyclonal Antibody
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FIGURE: 1 / 4
UCP1 Antibody (HA500118) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human fetal skeletal muscle tissue using anti-UCP1 antibody. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA500118, 1:400) for 30 minutes at room t... View More
Product Details
HA500118
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human UCP1 aa 233-266.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Mitochondrial uncoupling proteins are members of the family of mitochondrial anion carrier proteins. UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:12517; Mitochondrial brown fat uncoupling protein 1; Solute carrier family 25 member 7; Thermogenin; UCP 1; uncoupling protein; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial
Gene Aliases: AI385626; SLC25A7; UCP; UCP1; Ucpa; Uncp
UniProt ID: (Human) P25874, (Rat) P04633, (Mouse) P12242
Entrez Gene ID: (Human) 7350, (Rat) 24860, (Mouse) 22227
protein binding
GTP binding
hydrogen ion transmembrane transporter activity
oxidative phosphorylation uncoupler activity
GDP binding
transmembrane transporter activity
purine ribonucleotide binding
long-chain fatty acid binding
anion binding
cardiolipin binding
transporter
secondary carrier transporter
diet induced thermogenesis
regulation of transcription from RNA polymerase II promoter
ion transport
mitochondrial transport
response to temperature stimulus
response to cold
response to nutrient levels
cellular response to hormone stimulus
ion transmembrane transport
cellular response to reactive oxygen species
brown fat cell differentiation
transmembrane transport
cellular response to cold
cellular response to fatty acid
positive regulation of cold-induced thermogenesis
hydrogen ion transmembrane transport
regulation of reactive oxygen species biosynthetic process
cellular response to dehydroepiandrosterone
mitochondrial transmembrane transport
adaptive thermogenesis
generation of precursor metabolites and energy
proton transport
positive regulation of multicellular organismal metabolic process
response to steroid hormone
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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