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Product Details
PA5-116568
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide corresponding to amino acids 200-300 of human UCP4. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
2.66 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2901199 |
Product Specific Information
Positive Samples: mouse brain, rat brain
Target Information
UCP4 is a 323 amino acid mitochondrial uncoupling protein belonging to the large mitochondrial substrate carrier family with three Solcar repeats. UCP4 is a mitochondrial transport carrier that facilitates the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. It reduces the mitochondrial membrane potential in mammalian cells and is involved in thermoregulatory heat production. UCP4 creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis resulting in dissipation of energy in the form of heat. UCP4 is usually found in adult and fetal brain, with low levels in spinal chord, corpus callosum and substantia nigra.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitochondrial uncoupling protein 4; Solute carrier family 25 member 27; solute carrier family 25, member 27; UCP 4; uncoupling protein; uncoupling protein 4; uncoupling protein UCP-4
Gene Aliases: 3632410G24Rik; 9430092A03Rik; D530043E16Rik; SLC25A27; UCP4; UNQ772/PRO1566
UniProt ID: (Human) O95847
Entrez Gene ID: (Human) 9481, (Mouse) 74011, (Rat) 85262
Molecular Function:
transporter
secondary carrier transporter
generation of precursor metabolites and energy
translation
proton transport
positive regulation of cell proliferation
negative regulation of mitochondrial membrane potential
cellular triglyceride homeostasis
negative regulation of apoptotic process
regulation of glucose import
negative regulation of mitochondrial calcium ion concentration
neuron death
transport
inner ear development
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