Peptide sequence: LHLNKKATDK QPYSKLPGVS LLKPLKGVDP NLINNLETFF ELDYPKYEVL
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 77%; Zebrafish: 100%
May serve as a ""flippase"" as well as a glucosyltransferase that transfers glucose to ceramide. It Catalzes; UDP-glucose + Nacylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ceramide glucosyltransferase; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21; GCS; GlcT; GLCT-1; GLCT1; Glucosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:ceramide glycosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
Gene Aliases: AU043821; BOS_9351; C80537; cb539; Epcs21; GCS; GlcT-1; GLCT1; sb:cb539; UGCG; Ugcgl; zgc:112506