Immunogen sequence: RLHLNKKATD KQPYSKLPGV SLLKPLKGVD PNLINNLETF FELDYPKYEV LLCVQDHDDP AIDVCKKLLG KYPNVDARLF IGGKKVGINP KINNLMPGYE VAKYDLI
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 98%.
May serve as a "flippase" as well as a glucosyltransferase that transfers glucose to ceramide. It Catalyzes; UDP-glucose + Nacylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ceramide glucosyltransferase; GCS; GLCT-1; Glucosylceramide synthase; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
Gene Aliases: GCS; GLCT1; UGCG
UniProt ID: (Human) Q16739
Entrez Gene ID: (Human) 7357
Molecular Function: glycosyltransferase