Immunogen sequence: EGTAIKDLKN PDRVLIGGDE TPEGQRAVQA LCAVYEHWVP REKILTTNTW SSELSKLAAN AFLAQRISSI NSISALCEAT GADVEEVATA IGMDQRIGNK FLKASVGFGG SCFQKDVLNL VYLCEALNLP EVARYWQQVI DMNDYQRRRF ASRIIDSLFN TVTDKKIAIL GFAFKKDTGD TRESSSIYIS KYLMDEGAHL HIYDPKVPRE QIVVDLSHPG VSEDDQVSRL VTISKDPYEA CDGAHAVVIC TEWDMFKELD YERIHKKMLK PAFIFDGRRV LDGLHNELQT IGFQIETIGK KVSSKRIPYA PSGEIPKFSL QDPPNKKPKV; Positive Samples: HeLa, THP-1, 22Rv1, ES-2, U-937, Mouse kidney, Mouse intestine
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.
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Protein Aliases: UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogeanse; UDP-glucose dehydrogenase; UDPGDH; uridine diphospho-glucose dehydrogenase
Gene Aliases: GDH; UDP-GlcDH; UDPGDH; UGD; UGDH