Immunogen sequence: DFILSHAVYC RDVLKLKKGQ RAVISNGRII GPLEDSELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV DALLSAQPKG DPRIEYQFFE DRHSAIKLRP KEGETYFDVV AVVDPV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction. UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids that are exposed in the denatured conformation. It is postulated that UGGT serves as a sensor that is able to distinguish between folded and denatured protein in the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RUGT; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein: glucosyltransferase UGGT; UDP-glucose:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1; UGT1
Gene Aliases: 0910001L17Rik; A930007H10Rik; AA589501; AI414429; AI448372; C820010P03Rik; GT; HUGT1; rUGT1; UGCGL1; UGGT; UGGT1; UGT1; UGTR
Molecular Function: glycosyltransferase