The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: testis tissue sperm-binding protein Li 58p; UDP-glucose diphosphorylase; UDP-glucose pyrophosphorylase; UDP-glucose pyrophosphorylase 1; UDPGP; UGPase 2; uridindiphosphoglucosepyrophosphorylase 2; uridyl diphosphate glucose pyrophosphorylase 2; Uridyl diphosphate glucose pyrophosphorylase-1; UTP--glucose-1-phosphate uridylyltransferase; UTP--glucose-1-phosphate uridylyltransferase 2; UTP-glucose-1-phosphate uridyltransferase
Gene Aliases: pHC379; UDPG; UDPGP; UDPGP2; UGP1; UGP2; UGPase; UGPP1; UGPP2