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Product Details
PA5-42553
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human UGT1A1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2609187
Product Specific Information
Peptide sequence: DGSHWLSMLG AIQQLQQRGH EIVVLAPDAS LYIRDGAFYT LKTYPVPFQR
Sequence homology: Horse: 86%; Human: 100%; Mouse: 79%; Rat: 82%
Target Information
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; Bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17; HUG BR1; hUG-BR1; HUGBR1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A isoform 1; UDP-glucuronosyltransferase 1A1; UDPGT 1-1; UGT 1A; UGT-1A; UGT1 01; UGT1*1; UGT1-01; UGT1.1; UGT1A1
Gene Aliases: BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; UGT1; UGT1A; UGT1A1
UniProt ID: (Human) P22309
Entrez Gene ID: (Human) 54658
liver development
bilirubin conjugation
acute-phase response
response to nutrient
digestion
steroid metabolic process
estrogen metabolic process
flavonoid biosynthetic process
drug metabolic process
organ regeneration
response to lipopolysaccharide
heme catabolic process
response to drug
retinoic acid metabolic process
response to starvation
negative regulation of catalytic activity
negative regulation of steroid metabolic process
heterocycle metabolic process
flavone metabolic process
cellular glucuronidation
flavonoid glucuronidation
xenobiotic glucuronidation
biphenyl catabolic process
cellular response to ethanol
cellular response to glucocorticoid stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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