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Product Details
PA5-89315
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human UGT1A1 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
2.96 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2805487 |
Product Specific Information
Immunogen sequence: MAVESQGGRP LVLGLLLCVL GPVVSHAGKI LLIPVDGSHW LSMLGAIQQL QQRGHEIVVL APDASLYIRD GAFYTLKTYP VPFQREDVKE SFVSLGHNVF ENDSFLQRVI KTYKKIKKDS AMLLSGCSHL LHNKELMASL AESSFDVMLT DPFLPCSPIV AQYLSLPTVF FLHALPCSLE FEATQCPNPF SYVPRPLSSH; Positive Samples: HepG2, HL-60, SH-SY5Y, SW480, mouse liver, mouse kidney, mouse lung, rat liver; Cellular Location: Endoplasmic reticulum, Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein
Target Information
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B1; bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; Bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17; HUG BR1; hUG-BR1; HUGBR1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A isoform 1; UDP-glucuronosyltransferase 1A1; UDPGT; UDPGT 1-1; UGT 1A; UGT-1A; UGT1 01; UGT1*1; UGT1-01; UGT1.1; UGT1A1; UGTBR1
Gene Aliases: BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; Udpgt-1a; UGT1; UGT1A; UGT1A01; UGT1A1; UgtBr1
UniProt ID: (Human) P22309, (Mouse) Q63886, (Rat) Q64550
Entrez Gene ID: (Human) 54658, (Mouse) 394436, (Rat) 24861
Molecular Function:
glycosyltransferase
liver development
bilirubin conjugation
acute-phase response
response to nutrient
digestion
steroid metabolic process
estrogen metabolic process
flavonoid biosynthetic process
drug metabolic process
organ regeneration
response to lipopolysaccharide
heme catabolic process
response to drug
retinoic acid metabolic process
response to starvation
negative regulation of catalytic activity
negative regulation of steroid metabolic process
heterocycle metabolic process
flavone metabolic process
cellular glucuronidation
flavonoid glucuronidation
xenobiotic glucuronidation
biphenyl catabolic process
cellular response to ethanol
cellular response to glucocorticoid stimulus
metabolic process
response to organic substance
cellular response to hormone stimulus
negative regulation of cellular glucuronidation
response to organic cyclic compound
response to ethanol
response to steroid hormone
response to glucocorticoid
retinoic acid binding
enzyme inhibitor activity
steroid binding
glucuronosyltransferase activity
enzyme binding
protein homodimerization activity
protein heterodimerization activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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