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Proteintech
UGT1A6 Polyclonal Antibody
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Product Details
23765-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UGT1A6 fusion protein Ag20635
Conjugate
Form
Liquid
Concentration
600 µg/mL
Amount
90 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: CSLEHTFSRS PDPVSYIPRC YTKFSDHMTF SQRVANFLVN LLEPYLFYCL FSKYEELASA VLKRDVDIIT LYQKVSVWLL RYDFVLEYPR PVMPNMVFIG GINCKKRKDL SQEFEAYINA SGEHGIVVFS LGSMVSEIPE KKAMATADAL GKIPQTVLWR YTGTRPSNLA NNTILVKWLP QNDLLGHPMT RAFITHAGSH GVYESICNGV PMVMMPLFGD QMDNAKRMET KGAGVTLNVL EMTSEDLENA LKAVINDKSY KENIMRLSSL HKDRPVEPLD LAVFWVEFVM RHKGAPHLRP AAHDLTWYQY HSL
Target Information
UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1; Bilirubin-specific UDPGT isozyme 1; MGC29860; P-nitrophenol specific; P-nitrophenol-specific UDPGT; Phenol UDP-glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-5; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A3; UDP-glucuronosyltransferase 1A5; UDP-glucuronosyltransferase 1A6; UDPGT 1-6; UGP1A1; UGT-1F; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A7
Gene Aliases: GNT1; HLUGP; HLUGP1; hUG-BR1; UDPGT; UDPGT 1-6; UGT-1A; UGT-1C; UGT-1E; UGT-1F; UGT1; UGT1-01; UGT1-03; UGT1-05; UGT1-06; UGT1.1; UGT1.3; UGT1.5; UGT1.6; UGT1A; UGT1A1; UGT1A3; UGT1A5; UGT1A6; Ugt1a6a; UGT1A6S; Ugt1a7; UGT1C; UGT1E; UGT1F
UniProt ID: (Human) P19224, (Rat) P08430, (Mouse) Q64435
Entrez Gene ID: (Human) 54578, (Rat) 113992, (Mouse) 94284
retinoic acid binding
enzyme inhibitor activity
UDP-glycosyltransferase activity
glucuronosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
enzyme binding
protein homodimerization activity
protein heterodimerization activity
protein complex binding
transferase activity, transferring hexosyl groups
glycosyltransferase
xenobiotic metabolic process
negative regulation of fatty acid metabolic process
liver development
flavonoid biosynthetic process
response to organic cyclic compound
4-chlorobiphenyl metabolic process
response to lipopolysaccharide
cellular response to hormone stimulus
response to peptide hormone
flavonoid glucuronidation
xenobiotic glucuronidation
cellular response to glucocorticoid stimulus
metabolic process
glucuronate metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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