Invitrogen

UGT1A6 Polyclonal Antibody

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UGT1A6 Antibody in Western Blot (WB) — Western blot analysis of UGT1A6 in HeLa, HepG2, SW480, MCF7, mouse kidney. Samples were incubated in polyclonal UGT1A6 antibody (Product # PA5-110546) using a dilution of 1:1000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10000.

Product Details

PA5-110546

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2). View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.42 mg/mL
Purification	Affinity Chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2855957

Product Specific Information

Sequence of this protein is as follows: LLLKESKYYT RKIYPVPYDQ EELKNRYQSF GNNHFAERSF LTAPQTEYRN NMIVIGLYFI NCQSLLQDRD TLNFFKESKF DALFTDPALP CGVILAEYLG LPSVYLFRGF PCSLEHTFSR SPDPVSYIPR CYTKFSDHMT FSQRVANFLV NLLEPYLFYC LFSKYEELAS AVLKRDVDII TLYQKVSVWL LRYDFVLEYP RPVMPN

Target Information

UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A1; MGC29860; P-nitrophenol specific; P-nitrophenol-specific UDPGT; Phenol UDP-glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT 1-6; UGP1A1; UGT-1F; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A7

Gene Aliases: GNT1; HLUGP; HLUGP1; UDPGT; UDPGT 1-6; UGT1; UGT1-06; UGT1.6; UGT1A6; Ugt1a6a; UGT1A6S; Ugt1a7; UGT1F

UniProt ID: (Human) P19224, (Rat) P08430, (Mouse) Q64435

Entrez Gene ID: (Human) 54578, (Rat) 113992, (Mouse) 94284

Molecular Function: glycosyltransferase