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Product Details
PA5-62911
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UGT1A6. Recombinant protein control fragment (Product #RP-103807).
Conjugate
Form
Liquid
Concentration
Lot-Specific
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2649249
Product Specific Information
Immunogen sequence: WLSMKDIVEV LSDRGHEIVV VVPEVNLLLK ESKYYTRKIY PVPYDQEELK NRYQSFGNNH FAERSFLTAP QTEYRNNMIV IGLY
Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 73%.
Target Information
UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC29860; Phenol-metabolizing UDP-glucuronosyltransferase; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT 1-6; UGT-1F; UGT1*6; UGT1-06; UGT1.6
Gene Aliases: GNT1; HLUGP; HLUGP1; UDPGT; UDPGT 1-6; UGT1; UGT1A6; UGT1A6S; UGT1F
UniProt ID: (Human) P19224
Entrez Gene ID: (Human) 54578
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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