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UGT2B4 Polyclonal Antibody

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UGT2B4 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using UGT2B4 antibody 15425-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

UGT2B4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver using 15425-1-AP (UGT2B4 antibody) at dilution of 1:100 (under 40x lens).

UGT2B4 Antibody in Western Blot (WB) — Human liver tissue were subjected to SDS PAGE followed by western blot with 15425-1-AP (UGT2B4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

15425-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:10-1:100	-

Product Specifications
Species Reactivity	Human
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	UGT2B4 Fusion Protein Ag8058 (169-528 aa encoded by BC026264) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.18 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: VYSLRFSPG YAIEKHSGGL LFPPSYVPVV MSELSDQMTF IERVKNMIYV LYFEFWFQIF DMKKWDQFYS EVLGRPTTLS ETMAKADIWL IRNYWDFQFP HPLLPNVEFV GGLHCKPAKP LPKEMEEFVQ SSGENGVVVF SLGSMVSNTS EERANVIASA LAKIPQKVLW RFDGNKPDTL GLNTRLYKWI PQNDLLGHPK TRAFITHGGA NGIYEAIYHG IPMVGVPLFA DQPDNIAHMK AKGAAVSLDF HTMSSTDLLN ALKTVINDPL YKENAMKLSR IHHDQPVKPL DRAVFWIEFV MRHKGAKHLR VAAHDLTWFQ YHSLDVTGFL LACVATVIFI ITKCLFCVWK FVRTGKKGKR D (169-528 aa encoded by BC026264)

Target Information

UGT2B4 belongs to the UDP-glycosyltransferase family. UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.

Drug metabolism and disposition: the biological fate of chemicals

Barrett KG,Fang H,Cukovic D,Dombkowski AA,Kocarek TA,Runge-Morris M

Wed Jul 01 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: HLUG25; hyodeoxycholic acid; Hyodeoxycholic acid-specific UDPGT; UDP glucuronosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase 2B4; UDP-glucuronyltransferase, family 2, beta-4; UDPGT 2B4; UDPGTh-1

Gene Aliases: HLUG25; UDPGT2B4; UDPGTh-1; UDPGTH1; UGT2B11; UGT2B4

UniProt ID: (Human) P06133

Entrez Gene ID: (Human) 7363

Function(s)

estrogen catabolic process xenobiotic metabolic process metabolic process flavonoid biosynthetic process cellular glucuronidation flavonoid glucuronidation

Process(es)

retinoic acid binding glucuronosyltransferase activity

UGT2B4 Polyclonal Antibody

Product Details

15425-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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