UGT2B4 belongs to the UDP-glycosyltransferase family. UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
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Protein Aliases: HLUG25; hyodeoxycholic acid; Hyodeoxycholic acid-specific UDPGT; UDP glucuronosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase 2B4; UDP-glucuronyltransferase, family 2, beta-4; UDPGT 2B4; UDPGTh-1
Gene Aliases: HLUG25; UDPGT2B4; UDPGTh-1; UDPGTH1; UGT2B11; UGT2B4
UniProt ID: (Human) P06133
Entrez Gene ID: (Human) 7363