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UGT8 Antibody (PA5-103177) in ICC/IF
Immunofluorescent analysis of UGT8 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and UGT8 polyclonal antibody (Product # PA5-103177) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-103177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UGT8(Accession Q16880), corresponding to amino acid residues K318-W340.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2852547
Target Information
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; CGalT; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8; UDP-glucuronosyltransferase 8; uridine diphosphate glycosyltransferase 8
Gene Aliases: CGT; UGT4; UGT8; Ugt8a
UniProt ID: (Human) Q16880, (Rat) Q09426
Entrez Gene ID: (Human) 7368, (Rat) 50555
protein localization to paranode region of axon
galactosylceramide biosynthetic process
glycosphingolipid metabolic process
cytoskeleton organization
central nervous system development
peripheral nervous system development
flavonoid biosynthetic process
paranodal junction assembly
neuron projection morphogenesis
flavonoid glucuronidation
glycosphingolipid biosynthetic process
axo-dendritic transport
cellular response to hormone stimulus
myelination
Performance Guarantee
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