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Invitrogen
UGT8 Polyclonal Antibody
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FIGURE: 1 / 2
UGT8 Antibody (PA5-118340) in WB
Western Blot using UGT8 Polyclonal Antibody (Product # PA5-118340) at 1:500 dilution. Lane A: Mouse brain tissue lysate, Lane B: U-251 MG Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary antibody: Goat Anti-Rabbit IgG (H+L)/HRP at 1:10,000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 61 kDa. Observed band size: 61 kDa. (We are unsure of the identity of these extra bands).
Product Details
PA5-118340
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human UGT8 fragment
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; uridine diphosphate glycosyltransferase 8
Gene Aliases: CGT; UGT4; UGT8
UniProt ID: (Human) Q16880
Entrez Gene ID: (Human) 7368
protein localization to paranode region of axon
galactosylceramide biosynthetic process
glycosphingolipid metabolic process
cytoskeleton organization
central nervous system development
peripheral nervous system development
flavonoid biosynthetic process
paranodal junction assembly
neuron projection morphogenesis
flavonoid glucuronidation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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