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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to residues in human UGT8|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 61 kDa.
Purity is >95% by SDS-PAGE.
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
2-hydroxyacylsphingosine 1-beta-galactosyltransferase; ceramide UDP-galactosyltransferase; cerebroside synthase; CGT; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; UGT4; uridine diphosphate glycosyltransferase 8
AI850488; AW455908; CGT; mCerGT; UGT4; UGT8; Ugt8a