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Product Details
PA5-48251
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:2,000 | - |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:10-1:50 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Not Applicable |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide between 366-393 amino acids from the Central region of human UGT8. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Protein A, Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2633709 |
Product Specific Information
Predicted to react with rat based on sequence homology.
Target Information
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; uridine diphosphate glycosyltransferase 8
Gene Aliases: AI850488; AW455908; CGT; mCerGT; UGT4; UGT8; Ugt8a
UniProt ID: (Human) Q16880, (Mouse) Q64676
Entrez Gene ID: (Human) 7368, (Mouse) 22239
protein localization to paranode region of axon
lipid metabolic process
sphingolipid metabolic process
cytoskeleton organization
metabolic process
glycolipid biosynthetic process
flavonoid biosynthetic process
paranodal junction assembly
cellular response to hormone stimulus
myelination
neuron projection morphogenesis
flavonoid glucuronidation
galactosylceramide biosynthetic process
glycosphingolipid metabolic process
central nervous system development
peripheral nervous system development
2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
glucuronosyltransferase activity
N-acylsphingosine galactosyltransferase activity
ceramide glucosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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