RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
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Protein Aliases: BRCA1-A complex subunit RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1
Gene Aliases: 9430016E08Rik; D330018D10Rik; D630032M02Rik; RAP80; RIP110; RXRIP110; UIMC1; X2HRIP110