PA5-34965 targets ULK1 in WB applications and shows reactivity with Human and Rat samples.
The PA5-34965 immunogen is recombinant fragment contains a sequence corresponding to a region within amino acids 573 and 756 of ULK1.
ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
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Protein Aliases: ATG1 autophagy related 1 homolog; autophagy-related protein 1 homolog; serine/threonine-protein kinase ULK1; unc-51-like kinase 1
Gene Aliases: ATG1; ATG1A; hATG1; UNC51; Unc51.1
UniProt ID: (Human) O75385