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Invitrogen
ULK2 Polyclonal Antibody
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Product Details
PA5-22173
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human ULK2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, NT2D1, NIH-3T3.
Predicted reactivity: Mouse (94%), Rat (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC:2.7.11.1; Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase Unc51.2; Unc-51 like kinase 2; Unc-51-like kinase 2; unnamed protein product
Gene Aliases: A830085I22Rik; ATG1B; AU015340; KIAA0623; mKIAA0623; ULK2; Unc51.2
UniProt ID: (Human) Q8IYT8, (Mouse) Q9QY01
Entrez Gene ID: (Human) 9706, (Mouse) 29869, (Rat) 303206
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
autophagosome assembly
mitophagy
autophagy
signal transduction
nervous system development
axonogenesis
axon guidance
protein localization
regulation of autophagy
piecemeal microautophagy of nucleus
response to starvation
protein autophosphorylation
collateral sprouting
negative regulation of collateral sprouting
axon extension
reticulophagy
somatic sensory system development
protein phosphorylation
phosphorylation
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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