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Invitrogen
ULK3 Polyclonal Antibody
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Product Details
PA5-80207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at C-terminus of human ULK3 (427-454aa HTEVQNLMARAEYLKEQVKMRESRWEAD).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Brain Tissue, Rat Testis Tissue, Mouse Brain Tissue, Human Placenta Tissue, 22RV1 whole cell, SMMC whole cell. IHC: rat brain tissue, human lung cancer tissue. Flow: U20S cell, THP-1 cell.
Target Information
ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins. ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZP434C131; EC:2.7.11.1; FLJ90566; Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3; unnamed protein product
Gene Aliases: 1200015E14Rik; ULK3
UniProt ID: (Human) Q6PHR2, (Mouse) Q3U3Q1, (Rat) D3ZHP7
Entrez Gene ID: (Human) 25989, (Mouse) 71742, (Rat) 691171
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
autophagosome assembly
mitophagy
autophagy
smoothened signaling pathway
regulation of autophagy
piecemeal microautophagy of nucleus
response to starvation
negative regulation of smoothened signaling pathway
positive regulation of smoothened signaling pathway
protein autophosphorylation
reticulophagy
fibroblast activation
cellular senescence
protein phosphorylation
phosphorylation
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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