This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: GLKVTDAIVL LDREQGGKDK LQAHGIRLHS VCTLSKMLEI LEQQKKVDAE TVGRVKRFIQ ENVFVAANHN ASPLSIKEAP KELSFGARAE LPRIHPVA
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 85%.
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
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Protein Aliases: ODC; OMPdecase; OPRT; OPRTase; Orotate phosphoribosyltransferase; Orotidine 5'-phosphate decarboxylase; UMP synthase; Uridine 5'-monophosphate synthase; uridine monophosphate synthase
Gene Aliases: 1700095D23Rik; AA408257; AL033308; BB164745; OK/SW-cl.21; OPRT; UMPS