Search
Invitrogen
UMPS Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-89118
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human UMPS (NP_0003641)
Conjugate
Form
Liquid
Concentration
3.33 mg/mL
Amount
333 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TKDYGTKRLV EGTINPGETC LIIEDVVTSG SSVLETVEVL QKEGLKVTDA IVLLDREQGG KDKLQAHGIR LHSVCTLSKM LEILEQQKKV DAETVGRVKR FIQENVFVAA NHNGSPLSIK EAPKELSFGA RAELPRIHPV ASKLLRLMQK KETNLCLSAD V; Positive Samples: HT-29, U-87MG, HeLa, LO2, Mouse brain, Mouse kidney
Target Information
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: OMPdecase; OPRTase; orotate phosphoribosyltransferase; orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23); orotidine 5'-phosphate decarboxylase; UMP synthase; UMPS; unnamed protein product; Uridine 5'-monophosphate synthase; uridine monophosphate synthase
Gene Aliases: 1700095D23Rik; AA408257; AL033308; BB164745; ODC; OK/SW-cl.21; OPRT; UMPS
UniProt ID: (Human) P11172, (Mouse) P13439
Entrez Gene ID: (Human) 7372, (Mouse) 22247, (Rat) 288051
'de novo' pyrimidine nucleobase biosynthetic process
pyrimidine nucleotide biosynthetic process
UMP biosynthetic process
UDP biosynthetic process
pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
metabolic process
nucleoside metabolic process
female pregnancy
lactation
cellular response to drug
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support