Recommended positive controls: 293T, HeLa.
Predicted reactivity: Mouse (98%), Rat (98%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B
Gene Aliases: MUNC13; Munc13-2; UNC13; UNC13B; Unc13h2