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Invitrogen
UNC13B Polyclonal Antibody
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Product Details
PA5-90699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human UNC13B (NP_0063683)
Conjugate
Form
Liquid
Concentration
0.46 mg/mL
Amount
46 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE AETLMKDDEI CGTRNPTPHK ILLDTRFELP FDIPEEEARY WTYKWEQINA LGADNEYSSQ EESQRKPLPT AAAQCSFEDP DSAVDDRDSD YRSETSNSFP PPYHTASQPN ASVHQFPVPV RSPQQLLLQG SSRDSCNDSM QSYDLDYPER RAISPTSSSR YGSSCNVSQG SSQLSELDQY HEQDDDHRET DSIHSCHSSH SLSRDGQAGF GEQEKPLEVT GQAEKEAACE PKEMKEDATT HPPPDLVLQK; Positive Samples: 293T, LO2; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Membrane, Peripheral membrane protein, synapse
Target Information
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: contains C2 domains; homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B; UNC-13 homolog 1; unc-13 homolog A; unc-13-like; unc13 homolog 1; unnamed protein product
Gene Aliases: MUNC13; Munc13-1; Munc13-2; UNC13; Unc13a; UNC13B; Unc13h1; Unc13h2
UniProt ID: (Human) O14795, (Mouse) Q9Z1N9
Entrez Gene ID: (Human) 10497, (Mouse) 22249
exocytosis
signal transduction
chemical synaptic transmission
neuromuscular junction development
positive regulation of synaptic vesicle priming
synaptic vesicle docking
synaptic vesicle priming
synaptic transmission, glutamatergic
intracellular signal transduction
regulation of short-term neuronal synaptic plasticity
innervation
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of apoptotic process
positive regulation of protein secretion
acrosomal vesicle exocytosis
dense core granule priming
cellular response to glucose stimulus
neuronal dense core vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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