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Invitrogen
UNC5B Polyclonal Antibody
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FIGURE: 1 / 4
UNC5B Antibody (PA5-67631) in IHC (P)
Immunohistochemical analysis of UNC5B in paraffin-embedded Human colorectal cancer tissue using (left) UNC5B Polyclonal Antibody (Product # PA5-67631) at a 1:25 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Product Details
PA5-67631
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human UNC5B.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C. elegans; Netrin receptor UNC5B; p53-regulated receptor for death and life protein 1; p53RDL1; Protein unc-5 homolog 2; Protein unc-5 homolog B; transmembrane receptor Unc5H2; unc-5 homolog 2; unc-5 homolog B; unc5 homolog 2; unnamed protein product
Gene Aliases: 6330415E02Rik; A630020F16; D10Bwg0792e; P53RDL1; UNC5B; UNC5H2; UNQ1883/PRO4326
UniProt ID: (Human) Q8IZJ1, (Mouse) Q8K1S3
Entrez Gene ID: (Human) 219699, (Mouse) 107449
angiogenesis
apoptotic process
signal transduction
anterior/posterior axon guidance
netrin-activated signaling pathway
negative regulation of neuron apoptotic process
positive regulation of protein kinase B signaling
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
multicellular organism development
axon guidance
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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