This antibody is predicted to react with canine based on sequence homology.
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin -like domains and 2 type I thrombospondin motifs in the extracellular region.
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Protein Aliases: homolog of C. elegans transmembrane receptor Unc5; Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; Rostral cerebellar malformation protein; UNC-5 homolog 3; unc-5 homolog C; unc-5 homolog C (C. elegans); unc5 (C.elegans homolog) c; unc5 homolog 3; UNC5C; UNC5H3
Gene Aliases: B130051O18Rik; Rcm; UNC5C; UNC5H3
Molecular Function: receptor