Immunogen sequence: IYKSTKCNDM QQSGSCPRGP FCAFAHVEQP PLSDDLQPSS AVSSPTQPGP VLYMPSAAGD SVPVSPSSPH APDLSALLCR NSSLGSPSNL CGSPPGSIRK PPNLEGIVFP GES
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 86%.
Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RING finger protein unkempt homolog; unkempt homolog; Zinc finger CCCH domain-containing protein 5; zinc finger CCCH type domain containing 5; zinc finger CCCH-type containing 5; zinc finger CCCH-type domain containing 5
Gene Aliases: KIAA1753; UNK; UNKEMPT; ZC3H5; ZC3HDC5
UniProt ID: (Human) Q9C0B0
Entrez Gene ID: (Human) 85451