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Bethyl Laboratories
UPAR Polyclonal Antibody
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FIGURE: 1 / 1
UPAR Antibody (A304-462A) in WB
Detection of human glycosylated and deglycosylated UPAR by western blot. Samples: Whole cell lysate (50 µg) from U-937 cells incubated with (+) or without (-) TPA (200 nM, 72 hrs) and lysed using NETN lysis buffer. The lysate was then treated (+) or mock treated (-) with PnGASE F. Antibodies: Affinity purified rabbit anti-UPAR antibody (Product # A304-462A) (lot A304-462A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-462A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 150 to 200 of Human Urokinase-Type Plasminogen Activator (uPA) Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
Target Information
The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD87; Monocyte activation antigen Mo3; PLAUR; sCD87; soluble CD87; suPAR; u-PA receptor; U-PAR; u-plasminogen activator receptor form 2; unnamed protein product; Urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor
Gene Aliases: CD87; MO3; PLAUR; U-PAR; UPAR; URKR
UniProt ID: (Human) Q03405
Entrez Gene ID: (Human) 5329
positive regulation of protein phosphorylation
chemotaxis
signal transduction
blood coagulation
regulation of plasminogen activation
regulation of cell adhesion
regulation of proteolysis
positive regulation of homotypic cell-cell adhesion
urokinase plasminogen activator signaling pathway
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
regulation of fibrinolysis
positive regulation of release of cytochrome c from mitochondria
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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