Sequence of this protein is as follows: GPPLGGGEGE AESADTMPFV MLTRKGNKQQ FKILNVPMSS QLAANHWNQQ QAEQEERMRM KKLTLDINER QEQEDYQEML QSLAQRPAPA NTNRERRPRY QHPKGAPNAD LIFKTGGRRR
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
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Protein Aliases: hUpf2; Nonsense mRNA reducing factor 2; Regulator of nonsense transcripts 2; smg-3 homolog, nonsense mediated mRNA decay factor; Up-frameshift suppressor 2 homolog; yeast Upf2p homolog
Gene Aliases: HUPF2; KIAA1408; RENT2; smg-3; UPF2
UniProt ID: (Human) Q9HAU5
Molecular Function: RNA metabolism protein