Proteintech

UQCRC2 Polyclonal Antibody

Product Image Gallery

UQCRC2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using UQCRC2 antibody 14742-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

UQCRC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 14742-1-AP (UQCRC2 antibody) at dilution of 1:100 (under 40x lens).

UQCRC2 Antibody in Western Blot (WB) — Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 14742-1-AP (UQCRC2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

UQCRC2 Antibody in Flow Cytometry (Flow) — 1X10^6 HepG2 cells were stained with 0.2ug UQCRC2 antibody (14742-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1500.

UQCRC2 Antibody in Immunoprecipitation (IP) — IP result of anti-UQCRC2 (IP:14742-1-AP, 4ug; Detection:14742-1-AP 1:1000) with mouse brain tissue lysate 4000ug.

Product Details

14742-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 7 publications 7 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:20-1:200	-
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	-
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	UQCRC2 Fusion Protein Ag6432 (103-453 aa encoded by BC000484) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.13 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: IEAVGGKLS VTATRENMAY TVECLRGDVD ILMEFLLNVT TAPEFRRWEV ADLQPQLKID KAVAFQNPQT HVIENLHAAA YRNALANPLY CPDYRIGKVT SEELHYFVQN HFTSARMALI GLGVSHPVLK QVAEQFLNMR GGLGLSGAKA NYRGGEIREQ NGDSLVHAAF VAESAVAGSA EANAFSVLQH VLGAGPHVKR GSNTTSHLHQ AVAKATQQPF DVSAFNASYS DSGLFGIYTI SQATAAGDVI KAAYNQVKTI AQGNLSNTDV QAAKNKLKAG YLMSVESSEC FLEEVGSQAL VAGSYMPPST VLQQIDSVAN ADIINAAKKF VSGQKSMAAS GNLGHTPFVD EL (103-453 aa encoded by BC000484)

Target Information

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Bai YH,Zhan YB,Yu B,Wang WW,Wang L,Zhou JQ,Chen RK,Zhang FJ,Zhao XW,Duan WC,Wang YM,Liu J,Bao JJ,Zhang ZY,Liu XZ

Fri Sep 14 00:00:00 EDT 2018

A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Bai YH,Zhan YB,Yu B,Wang WW,Wang L,Zhou JQ,Chen RK,Zhang FJ,Zhao XW,Duan WC,Wang YM,Liu J,Bao JJ,Zhang ZY,Liu XZ

Fri Sep 14 00:00:00 EDT 2018

Glutathione Reduction of Patulin-Evoked Cytotoxicity in HEK293 Cells by the Prevention of Oxidative Damage and the Mitochondrial Apoptotic Pathway.

Journal of agricultural and food chemistry

Wang X,Jin C,Zhong Y,Li X,Han J,Xue W,Wu P,Xia X,Peng X

Wed Jul 25 00:00:00 EDT 2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Cell reports

Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

Tue May 01 00:00:00 EDT 2018

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.

Disease markers

Han Y,Sun S,Zhao M,Zhang Z,Gong S,Gao P,Liu J,Zhou J,Ma D,Gao Q,Wu P

Mon Feb 20 00:00:00 EST 2017

COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.

Journal of medical genetics

Martinez Lyons A,Ardissone A,Reyes A,Robinson AJ,Moroni I,Ghezzi D,Fernandez-Vizarra E,Zeviani M

Thu Dec 01 00:00:00 EST 2016

Mechanism of super-assembly of respiratory complexes III and IV.

Nature

Cogliati S,Calvo E,Loureiro M,Guaras AM,Nieto-Arellano R,Garcia-Poyatos C,Ezkurdia I,Mercader N,Vázquez J,Enriquez JA

Thu Nov 24 00:00:00 EST 2016

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.

Cell

Yang W,Nagasawa K,Münch C,Xu Y,Satterstrom K,Jeong S,Hayes SD,Jedrychowski MP,Vyas FS,Zaganjor E,Guarani V,Ringel AE,Gygi SP,Harper JW,Haigis MC

Thu Nov 03 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Complex III subunit 2; Core protein II; Cytochrome b-c1 complex subunit 2, mitochondrial; cytochrome bc-1 complex core protein II; U MC3DN5; ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial precursor (Complex III subunit II); ubiquinol-cytochrome c reductase core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2

Gene Aliases: 1500004O06Rik; MC3DN5; QCR2; UQCR2; UQCRC2

UniProt ID: (Human) P22695, (Mouse) Q9DB77, (Rat) P32551

Entrez Gene ID: (Human) 7385, (Mouse) 67003, (Rat) 293448

Molecular Function: metalloprotease