Immunogen sequence: NLKREILPKA LKDKGIAMES ITVYQTVAHP GIQGNLNSYY SQQGVPASIT FFSPSGLTYS LKHIQELSGD NIDQIKFAAI GPTT
Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 69%.
The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hydroxymethylbilane hydrolyase; Hydroxymethylbilane hydrolyase [cyclizing]; UROIIIS; Uroporphyrinogen-III cosynthase; Uroporphyrinogen-III synthase
Gene Aliases: UROIIIS; UROS
UniProt ID: (Human) P10746
Entrez Gene ID: (Human) 7390
Molecular Function: hydrolase