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Invitrogen
USH1C Polyclonal Antibody
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FIGURE: 1 / 4
USH1C Antibody (PA5-81109) in IHC (P)
Immunohistochemical staining of human USH1C in human colon-carcinoma with USH1C Polyclonal Antibody (Product # PA5-81109, 1:1,000, formalin-fixed paraffin embedded sections). Positive staining was localized to epithelium. Left panel: tissue incubated with primary antibody. Right panel: tissue incubated with mixture of primary antibody and antigen (recombinant protein).
Product Details
PA5-81109
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human USH1C/Harmonin protein (Met1-Phe552)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human USH1C/Harmonin.
Target Information
This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antigen NY-CO-38/NY-CO-37; Autoimmune enteropathy-related antigen AIE-75; Harmonin; PDZ domain protein; PDZ-73 protein; Protein PDZ-73; Renal carcinoma antigen NY-REN-3; unnamed protein product; Usher syndrome 1C (autosomal recessive severe) isoform USH1C_1; Usher syndrome 1C (autosomal recessive severe) isoform USH1C_2; Usher syndrome 1C (autosomal recessive, severe); Usher syndrome type-1C protein
Gene Aliases: AIE-75; AIE75; DFNB18; DFNB18A; NY-CO-37; NY-CO-38; PDZ-45; PDZ-73; PDZ-73/NY-CO-38; PDZ73; PDZD7C; USH1C; ush1cpst
UniProt ID: (Human) Q9Y6N9
Entrez Gene ID: (Human) 10083
G2/M transition of mitotic cell cycle
auditory receptor cell morphogenesis
sensory perception of sound
parallel actin filament bundle assembly
cell differentiation
regulation of microvillus length
inner ear morphogenesis
auditory receptor cell differentiation
photoreceptor cell maintenance
retinal cone cell development
neuromuscular process controlling balance
sensory perception of light stimulus
equilibrioception
actin filament bundle assembly
inner ear receptor stereocilium organization
protein-containing complex assembly
protein localization to microvillus
brush border assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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