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Proteintech
USP10 Polyclonal Antibody
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Product Details
19374-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
USP10 Fusion Protein Ag7233 (444-798 aa encoded by BC000263)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KFIPLYSKV QRPCTSTPMI DSFVRLMNEF TNMPVPPKPR QALGDKIVRD IRPGAAFEPT YIYRLLTVNK SSLSEKGRQE DAEEYLGFIL NGLHEEMLNL KKLLSPSNEK LTISNGPKNH SVNEEEQEEQ GEGSEDEWEQ VGPRNKTSVT RQADFVQTPI TGIFGGHIRS VVYQQSSKES ATLQPFFTLQ LDIQSDKIRT VQDALESLVA RESVQGYTTK TKQEVEISRR VTLEKLPPVL VLHLKRFVYE KTGGCQKLIK NIEYPVDLEI SKELLSPGVK NKNFKCHRTY RLFAVVYHHG NSATGGHYTT DVFQIGLNGW LRIDDQTVKV INQYQVVKPT AERTAYLLYY RRVDLL (444-798 aa encoded by BC000263)
Target Information
USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 10; MGC2621; ubiquintin c-terminal hydrolase related polypeptide; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10
Gene Aliases: 2610014N07Rik; KIAA0190; mKIAA0190; Ode-1; UBPO; Uchrp; USP10
UniProt ID: (Human) Q14694, (Mouse) P52479, (Rat) Q3KR59
Entrez Gene ID: (Human) 9100, (Mouse) 22224, (Rat) 307905
DNA repair
proteolysis
ubiquitin-dependent protein catabolic process
autophagy
cellular response to DNA damage stimulus
regulation of autophagy
protein deubiquitination
DNA damage response, signal transduction by p53 class mediator
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
translesion synthesis
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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