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Invitrogen
USP10 Polyclonal Antibody
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FIGURE: 1 / 1
USP10 Antibody (PA5-96706) in WB
Western blot analysis of USP10 in extracts of various cell lines. Samples were incubated with USP10 Polyclonal antibody (Product # PA5-96706) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96706
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 499-798 of human USP10 (NP_0051442)
Conjugate
Form
Liquid
Concentration
1.12 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FEPTYIYRLL TVNKSSLSEK GRQEDAEEYL GFILNGLHEE MLNLKKLLSP SNEKLTISNG PKNHSVNEEE QEEQGEGSED EWEQVGPRNK TSVTRQADFV QTPITGIFGG HIRSVVYQQS SKESATLQPF FTLQLDIQSD KIRTVQDALE SLVARESVQG YTTKTKQEVE ISRRVTLEKL PPVLVLHLKR FVYEKTGGCQ KLIKNIEYPV DLEISKELLS PGVKNKNFKC HRTYRLFAVV YHHGNSATGG HYTTDVFQIG LNGWLRIDDQ TVKVINQYQV VKPTAERTAY LLYYRRVDLL; Positive Samples: HepG2, Mouse brain; Cellular Location: Cytoplasm, Early endosome, Nucleus
Target Information
USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 10; MGC2621; ubiquintin c-terminal hydrolase related polypeptide; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10
Gene Aliases: 2610014N07Rik; KIAA0190; mKIAA0190; Ode-1; UBPO; Uchrp; USP10
UniProt ID: (Human) Q14694, (Mouse) P52479
Entrez Gene ID: (Human) 9100, (Mouse) 22224
DNA repair
proteolysis
ubiquitin-dependent protein catabolic process
autophagy
cellular response to DNA damage stimulus
regulation of autophagy
protein deubiquitination
DNA damage response, signal transduction by p53 class mediator
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
translesion synthesis
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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