Immunogen sequence: YLSVPLLIS HKRVLEVFFI PMDPRRKPEQ HRLVVPKKGK ISDLCVALSK HTGISPERMM VADVFSHRFY KLYQLEEPLS SILDRDDIFV YEVSGRIEAI EGSREDIVVP VYLRERTPAR DYNNSYYGLM LFGHPLLVSV PRDRFTWEGL YNVLMYRLSR YVTKPNSDDE DDGDEKEDDE EDKDDVPGPS TGGSLRDPEP EQAGPSSGVT NRCPFLLDNC LGTSQWPPRR RRKQLFTLQT VNSNGTSDRT TSPEEVHAQP YIAIDWEPEM KKRYYDEVEA EGYVKHDCVG YVMKKAPVRL QECI (441-743 aa encoded by B C000350)
USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.
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Protein Aliases: Deubiquitinating enzyme 11; RP4-659F15.2; Ubiquitin carboxyl-terminal hydrolase 11; ubiquitin carboxyl-terminal hydrolase, X-linked; Ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; Ubiquitin-specific-processing protease 11
Gene Aliases: UHX1; USP11
UniProt ID: (Human) P51784
Entrez Gene ID: (Human) 8237
Molecular Function: cysteine protease