PA5-30300 targets USP14 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-30300 immunogen is recombinant fragment corresponding to a region within amino acids 286 and 494 of Human USP14.
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This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: 60-kD subunit; ataxia; Deubiquitinating enzyme 14; dUB-type TGT for deubiquitinating enzyme; TGT; tRNA-guanine transglycosylase, 60-kD subunit; Ubiquitin carboxyl-terminal hydrolase 14; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); ubiquitin specific protease 14; ubiquitin specific protease 14 (tRNA-guanine transglycosylase); Ubiquitin thioesterase 14; ubiquitin thiolesterase 14; ubiquitin-specific process; ubiquitin-specific processing protease 14; Ubiquitin-specific-processing protease 14
Gene Aliases: 2610005K12Rik; 2610037B11Rik; AW107924; ax; C78769; nmf375; TGT; USP14