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Search Thermo Fisher Scientific
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22
Gene Aliases: AI427806; KIAA1063; USP22; USP3L
UniProt ID: (Human) Q9UPT9, (Mouse) Q5DU02
Entrez Gene ID: (Human) 23326, (Mouse) 216825, (Rat) 303201
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