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Product Details
17707-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
USP28 Fusion Protein Ag12003 (1-350 aa encoded by BC065928)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: MTAELQQDD AAGAADGHGS SCQMLLNQLR EITGIQDPSF LHEALKASNG DITQAVSLLT DERVKEPSQD TVATEPSEVE GSAANKEVLA KVIDLTHDNK DDLQAAIALS LLESPKIQAD GRDLNRMHEA TSAETKRSKR KRCEVWGENP NPNDWRRVDG WPVGLKNVGN TCWFSAVIQS LFQLPEFRRL VLSYSLPQNV LENCRSHTEK RNIMFMQELQ YLFALMMGSN RKFVDPSAAL DLLKGAFRSS EEQQQDVSEF THKLLDWLED AFQLAVNVNS PRNKSENPMV QLFYGTFLTE GVREGKPFCN NETFGQYPLQ VNGYRNLDEC LEGAMVEGDV ELLPSDHSVK Y (1-350 aa encoded by BC065928)
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 28; Ubiquitin carboxyl-terminal hydrolase 28; ubiquitin carboxyl-terminal hydrolase 28 variant 1; ubiquitin specific protease 28; Ubiquitin thioesterase 28; ubiquitin thiolesterase 28; Ubiquitin-specific-processing protease 28
Gene Aliases: 9830148O20Rik; AU022237; KIAA1515; mKIAA1515; USP28
UniProt ID: (Human) Q96RU2, (Rat) D3ZJ96, (Mouse) Q5I043
Entrez Gene ID: (Human) 57646, (Rat) 315639, (Mouse) 235323
Molecular Function:
cysteine protease
DNA damage checkpoint
DNA repair
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
Ras protein signal transduction
cell proliferation
response to ionizing radiation
protein deubiquitination
regulation of protein stability
cellular response to UV
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
proteolysis
Performance Guarantee
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